A system includes a timing determination module configured to be disposed onboard an approaching vehicle system during travel of the approaching vehicle system along a first route toward a crossing between the first route and a second route. The purified paramyosin is used in vaccines for humans and bovine animals to induce immunity against schistosomal infection. Chemical Formula 1 1wherein R1, R2, R3 and R4 are, respectively, groups which may be the same or different and independently represent an aryl group of the following general formula.