The invention is directed to an improved toothbrush and methods of brushing. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. The copolymer may be employed alone or combined with one or more other ingredients in the ink-receiving layer including pigment, supplemental binder, and the like in order to fabricate an effective media product ideally suited for inkjet image generation using a wide variety of inks. The OLT includes dual lines and selectively outputs an Internet data signal.