The present invention provides a compound of formula I: 1or a pharmaceutically acceptable salt or mixtures thereof. In one embodiment, the apparatus comprises a server performing real-time receipt and encapsulation of the EAS data, transport of the EAS data to client devices over an IP or other packet-switched network, and use of applications running on the client devices to decode and display the EAS data. The filler neck includes a one-piece seamless funnel member having a tubular body and an elongated tubular member. The panel, which can also be \u201csnapped on\u201d a garment, appears as a permanent part of the garment, not as an add on to the garment. The toner flowing-out preventing valve is configured to open and close the communicating part in conjunction with rotation of the auger screw. The exoskeleton diverts the potential dangerous forces to the strong parts of the body and resists the generated forces when it reaches dangerous anatomical positions.