The present invention relates to Substituted Biaryl Derivatives, compositions comprising a Substituted Biaryl Derivative, and methods of using the Substituted Biaryl Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient. Said anchorage portion displays an elongate surface section with barbs, while said hook portion displays a short surface section with corresponding barbs in order, in a position with the barbs cooperating, to cause the retention of said hook portion against the anchorage portion in one set position selectable from among a plurality of such positions. A second free-form reflector is configured to receive the non-collimated light reflected from the secondary reflector. The pen also includes a user interface provided by one or more potentiometers or control buttons such that the user may modify the attributes. The constraints are associated with transmission line bandwidth or receiver buffer size.