The pneumatic sanding roll has an elongate housing with an outside driving axle separated from an inside portion by a large diameter disc. The first part comprises a plate on which a through hole is formed centrally, within the plate. Two arcuate members are provided along the top edges of the box. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, andor prevention of various diseases andor disorders related to these polypeptides.