Methods and apparatus for maximizing speech intelligibility use psycho-acoustic variables of a model of speech perception to control the determination of optimal frequency-band specific gain adjustments. The invention thus relates to the plants, seeds and tissue cultures of tomato variety Picus and to methods for producing a tomato plant produced by crossing a plant of tomato variety Picus with itself or with another tomato plant, such as a plant of another variety. The two transponders of each pair are aligned in parallel to the longitudinal axis of the vehicle, with at least one pair downstream and at least one pair upstream from the vehicle, and providing distinct identification means. Trust proxies interpret assertions from other federated domains as necessary. The retainer is retained in the mounting slot and has a locking projection protruding into the first cavity to lock with the electronic card. The invention also refers to a process for the preparation of ticagrelor or a pharmaceutically acceptable salt thereof from 4,6-dihalo-2-pyrimidin-5-amine of formula.