According to one embodiment, a keyboard unit that includes a keyboard body having a key top and a detecting unit detecting water. Electrical activity is induced in the thermoelectric layer by applying heat from the probe. Given the frequent amplification of 1q in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer. The historical information related to the location andor condition of the collateral is periodically stored in a database that is accessible via a global computer network such as the Internet. The invention also provides the use of Exendin conjugate for lowering body weight. The first and second request-response protocols respectively have first and second sets of start-codes for initiating the establishment of the connection, a common predefined port being used for the first and second request-response protocols.