In a preferred embodiment, an expendable alignment ring is adapted for centering opposing conical surfaces of a transmission torque converter and an engine crankshaft. The insulative substrate has a top surface and a bottom surface. The present invention further provides methods and compositions relating to agents that specifically bind to MKPX, PTP4A1, PTPN7, FEM-2, DKFZP566K0524 or FLJ20313 for treatment and visualization of tumors in patients.