The invention is directed to a contact lens design and methods of manufacturing, fitting and using such lenses. A releasable athletic shoe sole includes a detachable lower sole; a mechanical release mechanism constructed to release when a predetermined force is applied; and a longitudinal guiding element. The latching mechanism is mounted in a longitudinal side of the main body and has a latching body. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor. The invention also relates to methods of regulating disorders, specifically disorders of the intestinal tract and related disorders, by administering a composition of the invention.