Hybrid semiconductor materials have an inorganic semiconductor incorporated into a hole-conductive fluorene copolymer film. The optical fiber provides single mode transmission and low bend loss. Thereby, the present invention can realize an improved data read speed by reducing the loading of the global inputoutput line. The method also requires measuring the amplitude and phase information of the I and Q data from the first and second mixers based upon the injected signal to provide mismatch information and utilizing the mismatch information to compensate the I data and the Q data during normal operating mode. The non-myocytical marker preferably is galectin-3 or thrombospondin-2.