A structural element in the front region of a motor vehicle is arranged between an engine subframe and a bulkhead of the motor vehicle. A method to relief pain at the injection site of one or more implanted pharmaceutical pellets comprising the step of implanting one or more of Applicant’s implantable pellets. Desirably, at least a portion of the stem includes a surface permitting bony in-growth. The seal method comprises fitting the first splined inner-portion of the seal around at least a part of the splined portion of the first member, and fitting the second splined inner-portion of the seal around at least a part of the splined portion of the second member.