A combined patient interface and integrated exhaust assembly that passes a controlled flow of gas from an interior of a patient interface to ambient atmosphere at a predetermined flow rate irrespective of variations of pressure in the interior of the patient interface device relative to ambient atmosphere. A fastener device is mounted to the catheter. The enclosing area wiring pattern is a part of the connection wiring pattern and covers the enclosing area. Supplementation of the plasma-like solution with certain ions is described. A pull tab unit is fixed by the joint portions of the main body for facilitating the manipulation of pulling the zipper slide.