The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. A first end of the feed-forward resistive element is coupled to an output of the voltage-to-current converter and to an input of the buffer. To that end, embodiments of the invention automate some steps of such a configuration change operation that were previously performed manually, and coordinate those steps with other steps of the operation using a procedure stored as instructions on a computer readable media and executed by a computer system in order to effect and validate a correct sequencing of the steps. Initial and subsequent bandwidth allocation protocols may be utilized to allow peer nodes to coordinate communication opportunities between the peer nodes without impacting or having knowledge about reservations for communications with other peers. Electrosurgery mode includes asynchronous pacing, such as DOO mode providing atrial and ventricular pacing at previously programmed rate, AV delay, amplitudes, and pulse widths. Also disclosed are methods of making the compounds.