The present invention relates to compounds of general formula, wherein R1-R4 have the meanings given in the specification, A is CH2, CHOH or CH\u2014, B and C are independently CH2 or CH\u2014, and R5 is an aryl or heteroaryl group optionally substituted by the substituents listed in the specification. The technology is one of using a water fuel system for the internal combustion engine, as well as other use which require the use of fossil fuels, nuclear energy, hydroelectric or other sources of energy. The actuator can move the first cam between a first position and a second position along a first axis to move the steerable portion of the medical device along a first plane. The precipitated solids are collected in the lower section of the second evaporation chamber. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition . The method includes allocating a pool of GTs to a Gateway Location Register that is associated with the VPMN, where the pool of Global Titles corresponds to at least one of: one or more VLRs associated with the VPMN, one or more SGSNs associated with the VPMN, one or more HPMNs, and one or more HLRs associated with an HPMN from the one or more HPMNs.