A sewing machine having a detection device for movements of objects is provided. They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes. The buddy list server 28 calculates the distance between the user and the buddies from the location information of the mobile station 11 and the location information of the requested buddies in accordance with the poling by the mobile station 11, determines the proximity by comparing the distance with a threshold value that is set by the user, and transmits the proximity to the mobile station 11. Endocrine and exocrine pancreas, liver, lung, kidney, heart, cartilage, vascular, tendon, ligament and bone cells are induced in stem cells by Signal-plexes derived from each of the foregoing tissues as shown by morphology, immunostaining, ELISA, and RT-PCR analysis.