In an apparatus and process for manufacturing a detergent bar, the bar comprises a first distinct zone comprising a first component and at least a second distinct zone comprising a second component. The method includes providing the target object having the surface cavity. The present invention further relates to a system for holding fiber optic connectors including a fiber optic connector holder mounted within an opening in a bulkhead for mounting a fiber optic adapter. In particular, the invention relates to the use of a guanidine-rich oligonucleotides to disrupt disease-causing protein aggregates, for example, Huntington’s Disease protein aggregates . The head of the pin protrudes slightly above the face of the probe body so that aerodynamic and hydrodynamic forces are exerted directly against the pin, and pin displacement measures the forces directly.