The present invention is directed to a method of lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic which method comprises administering to said mammal an IgE lowering effective amount of a tetracycline such as minocycline or doxycline. The vessel can have a tubular body having a middle portion and at least one of a first tapered portion extending from a first end of the middle portion and a second tapered portion extending from a second end of the middle portion. The light-emitting device is formed over a first insulating layer made of an organic compound and a second insulating layer made of an inorganic insulating material containing nitrogen formed on the surface of the first insulating layer. In addition, the size of the pads may be increased while the width \u201cc\u201d of the IO cells does not have to be increased.