A method, system, and computer program product for cross-invalidation handling in a multi-level private cache are provided. The invention also relates to a method for inhibiting bacterial resistance in ESBLs-producing strains so as to have better control over the therapy; achieve reduced hospital stay and adjuvant step down therapy so as to avoid recrudescence. The at least one conductive pin includes a hollow lumen extending therethrough and is configured to extend through the at least one or more holes of the flange such that a proximal end of the at least one pin is in communication with the interior of the enclosure and a distal end of the at least one pin is in communication with the exterior of the enclosure. A capping layer is formed in the first trench. In still another embodiment, a portion of the encapsulating material or a support member to which the substrate is attached can be removed to define interlocking features that allow one microelectronic substrate package to be stacked on another and to resist relative movement between the two packages. The method may comprise: receiving an uplink grant; identifying a set of logical channels whose data are to be transmitted using the uplink grant; and performing a logical channel prioritization based on the identified set of logical channels.