A detergent granule comprising at least one composite material, wherein said at least one composite material comprises: a C10-C13 sodium linear alkylaryl sulfonate andor an alpha-sulfonated fatty acid ester such as methyl ester sulfonate; an alkaline agent, from about 0. The present invention further relates to methods for the preparation of compounds of Formula and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds andor pharmaceutical compositions in treating RAGE-mediated diseases. The transformer provides halogen bulb voltage and accepts a halogen bulb. If the positioning results which satisfy the requested accuracy do not exist, the server device 102 checks the accuracy request class, selects the positioning results with the highest positioning accuracy to respond to the client device 101 in the case of a second class, and notifies an error to the client device 101 in the case of a first class. The base for the detergent is a water soluble metal alkali such as sodium, potassium or lithium hydroxide, and a metal carbonate such as sodium, potassium or lithium carbonate.