A solid-state image pickup apparatus includes a substrate, a wiring layer, and a waveguide. The object consists of the coordination of the adaption of the codec operating modes in both transmission interfaces involved. An intermediate wafer having one or more intermediate contact pads is provided, where the intermediate contact pads are connected to an electro-optic arrangement on the intermediate wafer. \u201d The methods in accordance with the invention can be used to treat brain damage, brain disease, andor brain disorders. When the shuttle is IN the first and third pieces form a first magnetic latch to releasably hold it IN and when the shuttle is OUT the second and third pieces form a second magnetic latch to releasably hold it OUT. The invention provides for multifaceted bioimaging, including imaging of various cell types, such as stem cells.