The invention provides, inter alia, methods, devices and reagents for the preparation of native and non-denatured biomolecules using solid-phase extraction channels. A 2-alkyl-2-adamantanol is reacted with a carboxylic acid such as acrylic acid or the like in the presence of an acid catalyst such as concentrated sulfuric acid or the like and a drying agent composed of an acidic or neutral inorganic compound which is a solid at ordinary temperature in a dried state or of a water-absorbing high-molecular compound, to produce a 2-alkyl-2-admantyl ester. The List of Reference Characters which follows is intended to provide the reader with a convenient means of identifying elements of the invention in the Specification and Drawings. Hence, the electric field is applied to the traveling optical wave in a similar fashion to a traveling-wave modulator, except that the traveling wave has a much greater amplitude due to the build-up of energy inside the resonator. The second block is coupled to the needle to move the needle in the insertion direction and in a retraction direction, wherein movement of the second block in the insertion direction pushes the first block in the insertion direction.