This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. A subscribe message is sent from the client to a proxy server. If the second communications node switches to an idle state, the caching node is informed thereof by means of a sleep-event and takes over the sending of the messages for this node. A data stream converter may be used to process the information read by the reader into a format that is acceptable to the on-board computer. The cable base has a front end, a back end, and a seat adapted to receive a conductor cable. The at least one pellet of frozen sauce is positioned such that when it thaws it facilitates the thawing or heating of at least one of the first or second groups of ingredients.