An optimizing compiler device, a method, a computer program product which are capable of performing parallelization of irregular reductions. The adapter is a generally hollow tubular member having a cylindrical tapered outer wall and an inner wall concentric with the outer wall, with the inner wall being uniquely tapered to specified degrees depending on the shell gauge to be used. The foam filter of the first filter portion is, in use, exposed directly to a dust-laden airflow. The currently transmitted frequency is then compared with the received frequency to obtain a difference frequency from which an apparatus may estimate the distance. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.