A closed tip cryoprobe is advanced transorally or transrectally through the accessory channel of an endoscope to a region of interest in the gastrointestinal tract. In one embodiment, the invention comprises the step of orally administering to the human patient an effective amount of a vitamin D compound such as the onset of diabetes or diabetes symptoms is slowed. Content may be selected for delivery to the publisher from one or more content inventory. In one embodiment, a direct drive transmission is provided, and in a second embodiment a hydraulic motor is provided, for driving the inner two converging drums of each set.