The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, andor inflammatory diseases. When the media recording unit performs moving of the AV data from the data recording unit to the storage medium, the dubbing management information management unit updates the dubbing management information management unit corresponding to the AV data according to the determination result. The cooperating member extends rearwardly over the associated shelf. The backdrop programming is general local interest programming provided by the cable television network. In one embodiment, the phase shifting mask and the trim mask are exposed using the same exposure conditions, except for relative dosing. A pump structure re-circulates fluid and air through the re-circulation path during a pump mode.