A method and apparatus for positioning components of a brake system, which includes a push rod, a ball end coupled to the push rod, and a force transfer member placed between the push rod and the ball end. The finger, which can be detachable, is arranged and configured for cutting or scraping. When the computer is powered up and upon the condition that an OS in a hard disk of a computer system is damaged, the OS in the BIOS chip is executed. It is also provided screening assays for the selection of therapeutic agent as well as personalized medicine application based on drug sensitivityresistance or cancer markers. The valve closing member cooperates with at least one valve seat formed on the valve body and in a closed position, separates a system pressure region of the valve from a high pressure region.