Systems and methods for managing and providing content and services on a network system. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. Thereafter, estimates of at least one of frequency skew and phase offset between the master and slave clocks are acquired using a first algorithm, from the first timestamps accumulated in the first direction. The apparatus is capable of being used with different loads that operate at different peak to peak levels of alternating voltage.