The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. The preprocessor can include, for example, a uniformity corrector, a sampling filter, a modulation transformer, and a ditherer. Piezoelectric power generation is described that provides long term maintenance free power through automated recharging, for both locational devices and other electronic implants in a wide range of medical technologies. In addition, various coolant channels are vented to remove potential pockets of air in their upper regions. In particular it relates to a process for preparing vorinostat substantially free from impurities. Here, the unit phase change resistor cell comprises a phase change resistor and a hybrid switch.