Pharmaceutical compositions comprised of high molecular weight ATIII are discloses, as is the use thereof in treating infectious diseases, inflammatory disorders and diseases or conditions that are mediated by thrombin activation. Two ends of the bar body are respectively provided with two connecting sections respectively connecting with two handlebars. The polypeptides may be used within methods for stimulating the immune system, and proliferation andor development of hematopoietic cells in vitro and in vivo. The ad branding engine is configured to analyze user-published content and select at least one advertisement contextually related thereto.