The present invention relates to systems and methods for automatically and continuously regulating the level of nasal pressure to an optimal value during OSA treatment. 5 comprising 3% to 50% by weight of detergent active wherein nonionic detergent active when present, has a HLB in the range 5-18; and 0. The handle comprises a male handle portion and a female handle portion which can be joined together. The method of the invention can be employed in Multiple Input.