Methods are disclosed for determining an immunosuppressant drug in a sample suspected of containing an immunosuppressant drug. When this metal oxide fine powder is used as the external additive, such as the toner for the, electronic photograph, the standup of the electrostatic charge, the image quality, and the cleaning characteristic are improved remarkably. The reservoir may locally deliver a microdose amount of a substance to a target tissue. The proposal of this invention is to protect all contact surfaces of food slices\u2014even after their consumption has already started\u2014when closing entrance doors to a possible contamination, especially for protein food with high moisture content, such as cheeses and sausages which are excellent means of microbial culture. , fixed codebook gain, is modified in the speech signal in a variable and cyclical manner over a plurality of frames or sub-frames so that gain is temporally dispersed over a plurality of frames or sub-frames. During operation of the motorcycle, suction pressure within the motorcycle exhaust pipe and first cylindrical member creates vacuum pressure within the port apparatus, which draws crankcase gases through the hose and port apparatus for delivery to the first cylindrical member and ejection though the motorcycle exhaust pipe.