The present invention generally relates to a method for making colored contact lenses, in particular to colored silicone hydrogel contact lenses. An interface unit receives a luminance setting signal that specifies the luminance for each channel. The electrode contact of the permanently implantable neurostimulation lead comprises an elongated, flexible, coiled wire or mesh electrode having an exposed electrode length that is adapted to be inserted through the foramen from a posterior access to locate the coiled wire electrode alongside the sacral nerve extending anteriorly andor posteriorly therefrom. Also provided are methods of inhibiting a regulatory T cell-mediated immune suppression, or more generally a method for enhancing immune response using a pharmaceutical composition comprising a ligand for human Toll-like receptor 8 which activates the MyD88-IRAK4 signalling pathway.