Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. Thereby the increase of adipose cells can be suppressed and the blood glucose level can be reduced safely and effectively. The mark is formed in the same layer as that of an uppermost layer wiring in an integrated circuit formation region. This provides the response factor of the ICPMS or ICPOES for different elements. The compounds function as antiviral agents, they induce the biosynthesis of various cytokines including interferon, and they inhibit tumor formation in animal models.