A bioptical holographic laser scanning system employing a plurality of laser scanning stations about a holographic scanning disc having scanning facets with high and low elevation angle characteristics, as well as positive, negative and zero skew angle characteristics which strategically cooperate with groups of beam folding mirrors having optimized surface geometry characteristics. This invention also provides organic biomolecule markers useful for evaluating the therapeutic value of agents for treating kidney disease. The object is to achieve a higher hole concentration and thus conductivity of the p-doped layer. The precision of affixation afforded by this system is commensurate with philatelic standards and is suitable for all pressure adhesive indicia where rapid and precise placement is desired for aesthetic or other reasons.