Provided is a particle capable of being inserted into or taken up by a cell comprising i) a polynucleotide coding for a modulator of Notch signalling; and ii) a polynucleotide coding for an antigen or antigenic determinant thereof. A connecting rod movably connects to the moving part and to the payload. In one application, the ruthenium oxide catalysts are used in the final contact stage for conversion of SO2 to SO3 in multiple stage catalytic converters used in sulfuric acid manufacture. The weighing multiple is multiplied by the weighing value of each subfield to obtain a product capable of having a positive integer part and a fractional part.