A pedal assembly having a hysteresis creating configuration in communication with a sensor of a pedal assembly. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect. Where the tester is a human user, a test session can be dynamic and respond to human user feedback of game events.