A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. Additional bendable plate members may be positioned on opposite lateral sides of the plurality of spaced-apart rigid plate members. One of the first dielectric material and the second dielectric material comprises an organic material, and the other dielectric material comprises an inorganic material. These privileges are evaluated upon the individual’s application, and are periodically updated at the discretion of the controlling institution. The conditioning tool is adapted to condition a polishing pad of a polishing tool.