The invention concerns the use of hydrosoluble homopolymers andor copolymers of acrylicor methacrylic acid with one or more acrylic, vinyl or ally monomers as an aid to the grinding of mineral particles in aqueous suspension, providing them by their use particular optical properties. An output signal is generated phase locked to the first feedback signal by frequency dividing the output signal by the temporally-varying divide ratio sequence to generate a second feedback signal and phase comparing the second feedback signal with the first feedback signal. The network switches are configured for implementing the network management policy by storing switching actions for prescribed data packets, and templates that specify frame data parameters for identifying the prescribed data packets. The multiplied values are then weighed and added to the phase current values. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma, congenital adrenal hyperplasia and Cushing’s syndrome.