The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this composition. The leading end region of the dowel body in the setting direction has an internal thread acting as a load application means, and the oppositely located, trailing end region has at least one axially extending slit, and serves to receive the expansion sleeve. The X-ray beam manipulator device comprises an adjustable X-ray beam diaphragm provided between the X-ray source and the X-ray detector. Also described is a method for producing the black composite oxide particle.