A shower of tobacco particles is admitted into the inlet at the top of and descends by gravity andor under the action of a driven cell wheel in a generally upright duct. A convexo-concave portion is radially formed at a neck of the diaphragm, which is stuck to a voice coil bobbin, to increase an adhesion area of the neck itself, thereby the endurance against input is improved. The cooling system is configured as a gravity feed system that does not require a powered fluid pump. The second is to support the transfer of a large amount of data by a single peripheral to local memory or other local peripherals. The present invention further relates to use of the described derivatives for the treatment of diseases and conditions related to PDE, for example male erectile dysfunction.