The present invention relates to a new microbial process for the preparation of the compound formula . The doughnut-like implant can include a detachable connector. A second device connected to the first device and the oscillator operates for generating the control signal to the oscillator in response to the reference clock signal generated by the oscillator and the reference information extracted by the first device, and for locking a phase of the reference clock signal to the reference information. The cooling air path is provided extending along the shield member on a side thereof opposite from the induction heating unit. The invention further provides a hierarchical DRM scheme wherein each packet of the media is associated with a different protection level. The proteoglycan of the invention is derived from domain I or perlecan.