The invention provides the compounds of formula . A plurality of chuck pins are disposed in the first disposition parts of the chuck base such that the chuck pins can be moved inward and outward, respectively. The method of the invention can reduce the incidence of vertebral fracure, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, andor reduce the incidence of non-vertebral fracture. Because this process can be accomplished in fuel channels of relatively larger flow areas while maintaining laminar flow, the pressure drop sustained is relatively low.