This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at least 15% of normal in cancer cells, a pyrimidine antagonist, and an anticancer agent to which the treated cancer is sensitive. These particles are synthesized by copolymerizing with functional and cross linking monomers in presence of at least one imprint metal ion in the form of ternary complex. In some embodiments, the method comprises forming a digital model of the jewelry item, forming a physical model of the jewelry item based on the digital model, and manufacturing the jewelry item in a lost wax process using the physical model. The color correction processes are arranged as a succession of processes so that the results of a color correction process form the input to a next such process in the succession.