A method includes determining one or more potential merges corresponding to a color set Ai and a color set Aj of N color sets, represented by A1 to AN, used in coloring polygons of a layout of an integrated circuit. Couplings are insertable into the open ends and are adaptable along a longitudinal axis of the housing. The data set can then be inserted into an applications program to form the computer executable code. Also disclosed are the use of agents a for the manufacture of a delivery device for the treatment or prevention of lung inflammation or a respiratory disease, and a delivery device for the treatment or prevention of lung inflammation or a respiratory disease that contains an agent as described herein.