The present invention relates to chemical compounds of Formula are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis. The sample is placed on the stage such that the center of the sample is substantially aligned with the center of rotation and a measurement assembly is located above the sample to examine the features optically. An appropriate shape of the blank has a base section and an arcuate section associated with the base section. On the basis of the notified result of the determination, the CPU controls a display unit, a speaker, a light generating unit, or a vibration generating unit to generate a predetermined stimulus in order to notify the external access.