A garment includes an outer garment having a skirt portion with an inner side and a pair of elastic tethers having first fastening elements, and an undergarment having a front panel and a pair of second fastening elements. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like. The present invention further provides polymeric materials and optical devices made using these compositions. The weighting coefficients are initially set based on an MMSELS type of signal processing criteria, where the reference signal is the Training Sequence Code.