A tissue sampling device includes a cannula having an elongate tubular body with a sharpened coring tip. The optical guard rings are embedded in a stacked inter-metal dielectric layer between the sensor areas, that is, around each pixel. The nozzle plate and the front end are positioned and are bonded. The liquid containment covers are configured to contain cooling liquid passed from an inlet segment of the rotor cooling circuit defined by the rotor shaft into the plurality of longitudinal core passages, and thenceforth into an outlet segment of the rotor cooling circuit also defined by the rotor shaft. Using the covers over the straps allows the handler to tighten the straps much tighter than without the covers. Thereby, the second base is adapted to move with respect to the first base upon a plane along the first axis and the second axis to adjust the relative position of a second object and a first object disposed on the first base and the second base respectively.