An integrating optical system for measuring optical radiation. Pharmaceutical compositions comprising the compounds of formula are also disclosed. Whilst free to move axially, the lancet 36 is held against rotation and, following use, is released from the lancet holder by rotating the lancet holder to disengage the lancet from the forwardly extending arms 28 thus freeing the lancet. The response server is further configured to create a record for each initiated communication as the initiated communication is occurring, and to create a report including at least a portion of the data from each record. 0106 where ASPH is an aspherical amount of the aspherical surface.