This disclosure describes a reduced pin bus that can be used on integrated circuits or embedded cores within integrated circuits. The methods focus on the prevention, or delayed onset or progression of, subchondral defects such as bone marrow edema or bone marrow lesion, and subchondral treatment to prevent the progression of osteoarthritis or degenerative disc disease in the spine and thereby treat pain. An outlet is formed downstream of the inlet for selectively discharging the granular material and fluid.