Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. The SIM can be authenticated by the telephone network, in the same way as for authenticating SIMs of telephone handset users in the network, and can in this way authenticate the user of the PC or the PC itself. The asynchronous debug interface works at a wide range of clock frequencies and allows read and write transactions to take place on a side channel, as well as within the on chip processor fabric without switching into a debug or test mode.